CWS appears for the first time as a psychiatric diagnosis in the DSM-5  . CWS is defined by experiencing at least two of five psychological symptoms—irritability, anxiety, depressed mood, sleep disturbance, appetite changes—and at least one of six physical symptoms—abdominal pain, shaking, fever, chills, headache, diaphoresis—after cessation of heavy cannabis use. Heavy cannabis use is defined as daily or near daily use for at least a few months. Withdrawal symptoms commonly occur 24 h to 72 h after last use  and persist for 1 to 2 weeks. Sleep disturbance is often reported for up to 1 month. CWS may impede cannabis cessation and precipitate relapse  .